John Hardy

Research topics

• Alzheimer's disease research and treatments · 3 papers
• Dementia and Cognitive Impairment Research · 3 papers
• Cholinesterase and Neurodegenerative Diseases · 1 paper
• Prion Diseases and Protein Misfolding · 1 paper
• Genetics, Aging, and Longevity in Model Organisms · 1 paper
• GDF15 and Related Biomarkers · 1 paper

Frequent co-authors

• Dennis J. Selkoe · 2 papers
• Gerald A. Higgins · 1 paper
• Ian Grant McKeith · 1 paper
• Dennis W. Dickson · 1 paper
• James S Lowe · 1 paper
• Murat Emre · 1 paper
• John Tiernan O'Brien · 1 paper
• Howard Feldman · 1 paper

Papers

1. The Amyloid Hypothesis of Alzheimer's Disease: Progress and Problems on the Road to TherapeuticsScience · 2002 · 14,041 citations

   It has been more than 10 years since it was first proposed that the neurodegeneration in Alzheimer's disease (AD) may be caused by deposition of amyloid beta-peptide (Abeta) in plaques in brain tissue. According to the amyloid hypothesis, accumulation of…

2. Alzheimer's Disease: The Amyloid Cascade HypothesisScience · 1992 · 7,616 citations

   In both metazoan development and metastatic cancer, migrating cells must carry out a detailed, complex program of sensing cues, binding substrates, and moving their cytoskeletons. The linker cell in Caenorhabditis elegans males undergoes a stereotyped migration that guides gonad organogenesis,…

3. The amyloid hypothesis of Alzheimer's disease at 25 yearsEMBO Molecular Medicine · 2016 · 6,383 citations

   Despite continuing debate about the amyloid β-protein (or Aβ hypothesis, new lines of evidence from laboratories and clinics worldwide support the concept that an imbalance between production and clearance of Aβ42 and related Aβ peptides is a very early, often…

4. Diagnosis and management of dementia with Lewy bodiesNeurology · 2005 · 5,143 citations

   The dementia with Lewy bodies (DLB) Consortium has revised criteria for the clinical and pathologic diagnosis of DLB incorporating new information about the core clinical features and suggesting improved methods to assess them. REM sleep behavior disorder, severe neuroleptic sensitivity,…

5. Mild cognitive impairment – beyond controversies, towards a consensus: report of the International Working Group on Mild Cognitive ImpairmentJournal of Internal Medicine · 2004 · 5,035 citations

   The First Key Symposium was held in Stockholm, Sweden, 2-5 September 2003. The aim of the symposium was to integrate clinical and epidemiological perspectives on the topic of Mild Cognitive Impairment (MCI). A multidisciplinary, international group of experts discussed the…