Alzheimer's disease research and treatments

Most cited papers

1. Clinical diagnosis of Alzheimer's diseaseNeurology · 1984 · 28,112 citations
2. The diagnosis of dementia due to Alzheimer's disease: Recommendations from the National Institute on Aging‐Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's diseaseAlzheimer s & Dementia · 2011 · 19,187 citations
3. The Amyloid Hypothesis of Alzheimer's Disease: Progress and Problems on the Road to TherapeuticsScience · 2002 · 14,041 citations
4. NIA‐AA Research Framework: Toward a biological definition of Alzheimer's diseaseAlzheimer s & Dementia · 2018 · 10,970 citations
5. The diagnosis of mild cognitive impairment due to Alzheimer's disease: Recommendations from the National Institute on Aging‐Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's diseaseAlzheimer s & Dementia · 2011 · 10,470 citations
6. Amyloid Oligomers Exacerbate Tau Pathology in a Mouse Model of TauopathyNeurodegenerative Diseases · 2012 · 10,394 citations
7. Gene Dose of Apolipoprotein E Type 4 Allele and the Risk of Alzheimer's Disease in Late Onset FamiliesScience · 1993 · 9,614 citations
8. Copper-Zinc Superoxide Dismutase (SOD1) Is Released by Microglial Cells and Confers Neuroprotection against 6-OHDA NeurotoxicityNeurosignals · 2012 · 9,013 citations
9. Mild cognitive impairment as a diagnostic entityJournal of Internal Medicine · 2004 · 7,992 citations
10. Alzheimer's Disease: The Amyloid Cascade HypothesisScience · 1992 · 7,616 citations
11. Toward defining the preclinical stages of Alzheimer's disease: Recommendations from the National Institute on Aging‐Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's diseaseAlzheimer s & Dementia · 2011 · 7,314 citations
12. Protein Misfolding, Functional Amyloid, and Human DiseaseAnnual Review of Biochemistry · 2006 · 6,508 citations
13. The amyloid hypothesis of Alzheimer's disease at 25 yearsEMBO Molecular Medicine · 2016 · 6,383 citations
14. Alzheimer's Disease: Genes, Proteins, and TherapyPhysiological Reviews · 2001 · 6,114 citations
15. Lecanemab in Early Alzheimer’s DiseaseNew England Journal of Medicine · 2022 · 5,761 citations
16. MR signal abnormalities at 1.5 T in Alzheimer's dementia and normal agingAmerican Journal of Roentgenology · 1987 · 5,456 citations
17. Frontotemporal lobar degenerationNeurology · 1998 · 5,102 citations
18. Copper induces cell death by targeting lipoylated TCA cycle proteinsScience · 2022 · 5,052 citations
19. Effects of age, sex, and ethnicity on the association between apolipoprotein E genotype and Alzheimer disease. A meta-analysis. APOE and Alzheimer Disease Meta Analysis ConsortiumJAMA · 1997 · 4,825 citations
20. Current Concepts in Mild Cognitive ImpairmentArchives of Neurology · 2001 · 4,822 citations
21. Diagnosis and management of dementia with Lewy bodiesNeurology · 2017 · 4,591 citations
22. Imaging brain amyloid in Alzheimer's disease with Pittsburgh Compound‐BAnnals of Neurology · 2004 · 4,546 citations
23. Physical basis of cognitive alterations in alzheimer's disease: Synapse loss is the major correlate of cognitive impairmentAnnals of Neurology · 1991 · 4,494 citations
24. Amyloid plaque core protein in Alzheimer disease and Down syndrome.Proceedings of the National Academy of Sciences · 1985 · 4,481 citations
25. Apolipoprotein E: high-avidity binding to beta-amyloid and increased frequency of type 4 allele in late-onset familial Alzheimer disease.Proceedings of the National Academy of Sciences · 1993 · 4,321 citations
26. Correlative Memory Deficits, Aβ Elevation, and Amyloid Plaques in Transgenic MiceScience · 1996 · 4,251 citations
27. A new rating scale for Alzheimer's diseaseAmerican Journal of Psychiatry · 1984 · 4,235 citations
28. Common Structure of Soluble Amyloid Oligomers Implies Common Mechanism of PathogenesisScience · 2003 · 4,104 citations
29. Consensus guidelines for the clinical and pathologic diagnosis of dementia with Lewy bodies (DLB)Neurology · 1996 · 3,984 citations
30. Clinical and Biomarker Changes in Dominantly Inherited Alzheimer's DiseaseNew England Journal of Medicine · 2012 · 3,918 citations
31. β-Secretase Cleavage of Alzheimer's Amyloid Precursor Protein by the Transmembrane Aspartic Protease BACEScience · 1999 · 3,910 citations
32. Association of apolipoprotein E allele ϵ4 with late‐onset familial and sporadic Alzheimer's diseaseNeurology · 1993 · 3,829 citations
33. Oxidative Stress, Glutamate, and Neurodegenerative DisordersScience · 1993 · 3,797 citations
34. Abnormal phosphorylation of the microtubule-associated protein tau (tau) in Alzheimer cytoskeletal pathology.Proceedings of the National Academy of Sciences · 1986 · 3,717 citations
35. Intraneuronal β-Amyloid Aggregates, Neurodegeneration, and Neuron Loss in Transgenic Mice with Five Familial Alzheimer's Disease Mutations: Potential Factors in Amyloid Plaque FormationJournal of Neuroscience · 2006 · 3,680 citations
36. Phases of Aβ-deposition in the human brain and its relevance for the development of ADNeurology · 2002 · 3,631 citations
37. Diffusible, nonfibrillar ligands derived from Aβ 1–42 are potent central nervous system neurotoxinsProceedings of the National Academy of Sciences · 1998 · 3,550 citations
38. Complement and microglia mediate early synapse loss in Alzheimer mouse modelsScience · 2016 · 3,536 citations