Dennis J. Selkoe

Research topics

• Alzheimer's disease research and treatments · 4 papers
• Cholinesterase and Neurodegenerative Diseases · 2 papers
• Tryptophan and brain disorders · 2 papers
• Prion Diseases and Protein Misfolding · 1 paper
• Dementia and Cognitive Impairment Research · 1 paper
• Computational Drug Discovery Methods · 1 paper

Frequent co-authors

• John Hardy · 2 papers
• Soyon Hong · 1 paper
• Victoria F. Beja-Glasser · 1 paper
• Bianca M. Nfonoyim · 1 paper
• Arnaud Frouin · 1 paper
• Shaomin Li · 1 paper
• Saranya Ramakrishnan · 1 paper
• Katherine M. Merry · 1 paper

Papers

1. The Amyloid Hypothesis of Alzheimer's Disease: Progress and Problems on the Road to TherapeuticsScience · 2002 · 14,041 citations

   It has been more than 10 years since it was first proposed that the neurodegeneration in Alzheimer's disease (AD) may be caused by deposition of amyloid beta-peptide (Abeta) in plaques in brain tissue. According to the amyloid hypothesis, accumulation of…

2. The amyloid hypothesis of Alzheimer's disease at 25 yearsEMBO Molecular Medicine · 2016 · 6,383 citations

   Despite continuing debate about the amyloid β-protein (or Aβ hypothesis, new lines of evidence from laboratories and clinics worldwide support the concept that an imbalance between production and clearance of Aβ42 and related Aβ peptides is a very early, often…

3. Alzheimer's Disease: Genes, Proteins, and TherapyPhysiological Reviews · 2001 · 6,114 citations

   Rapid progress in deciphering the biological mechanism of Alzheimer's disease (AD) has arisen from the application of molecular and cell biology to this complex disorder of the limbic and association cortices. In turn, new insights into fundamental aspects of protein…

4. Complement and microglia mediate early synapse loss in Alzheimer mouse modelsScience · 2016 · 3,536 citations

   Synapse loss in Alzheimer's disease (AD) correlates with cognitive decline. Involvement of microglia and complement in AD has been attributed to neuroinflammation, prominent late in disease. Here we show in mouse models that complement and microglia mediate synaptic loss early…