Takeshi Iwatsubo

Research topics

• Dementia and Cognitive Impairment Research · 3 papers
• Alzheimer's disease research and treatments · 2 papers
• Cholinesterase and Neurodegenerative Diseases · 1 paper
• Tryptophan and brain disorders · 1 paper
• Parkinson's Disease Mechanisms and Treatments · 1 paper
• Neurological and metabolic disorders · 1 paper

Frequent co-authors

• Paul S. S. Aisen · 2 papers
• Reisa Anne Sperling · 1 paper
• Laurel A. Beckett · 1 paper
• David Alan Bennett · 1 paper
• Suzanne Craft · 1 paper
• Anne M. Fagan · 1 paper
• Clifford R. Jack · 1 paper
• Jeffrey Alan Kaye · 1 paper

Papers

1. Toward defining the preclinical stages of Alzheimer's disease: Recommendations from the National Institute on Aging‐Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's diseaseAlzheimer s & Dementia · 2011 · 7,314 citations

   The pathophysiological process of Alzheimer's disease (AD) is thought to begin many years before the diagnosis of AD dementia. This long "preclinical" phase of AD would provide a critical opportunity for therapeutic intervention; however, we need to further elucidate the…

2. Lecanemab in Early Alzheimer’s DiseaseNew England Journal of Medicine · 2022 · 5,761 citations

   BACKGROUND: The accumulation of soluble and insoluble aggregated amyloid-beta (Aβ) may initiate or potentiate pathologic processes in Alzheimer's disease. Lecanemab, a humanized IgG1 monoclonal antibody that binds with high affinity to Aβ soluble protofibrils, is being tested in persons with…

3. Diagnosis and management of dementia with Lewy bodiesNeurology · 2005 · 5,143 citations

   The dementia with Lewy bodies (DLB) Consortium has revised criteria for the clinical and pathologic diagnosis of DLB incorporating new information about the core clinical features and suggesting improved methods to assess them. REM sleep behavior disorder, severe neuroleptic sensitivity,…