Paul S. S. Aisen

Research topics

• Alzheimer's disease research and treatments · 3 papers
• Dementia and Cognitive Impairment Research · 3 papers
• Cholinesterase and Neurodegenerative Diseases · 1 paper
• Tryptophan and brain disorders · 1 paper
• Intracerebral and Subarachnoid Hemorrhage Research · 1 paper

Frequent co-authors

• Reisa Anne Sperling · 2 papers
• Anne M. Fagan · 2 papers
• Takeshi Iwatsubo · 2 papers
• Randall John Bateman · 2 papers
• Laurel A. Beckett · 1 paper
• David Alan Bennett · 1 paper
• Suzanne Craft · 1 paper
• Clifford R. Jack · 1 paper

Papers

1. Toward defining the preclinical stages of Alzheimer's disease: Recommendations from the National Institute on Aging‐Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's diseaseAlzheimer s & Dementia · 2011 · 7,314 citations

   The pathophysiological process of Alzheimer's disease (AD) is thought to begin many years before the diagnosis of AD dementia. This long "preclinical" phase of AD would provide a critical opportunity for therapeutic intervention; however, we need to further elucidate the…

2. Lecanemab in Early Alzheimer’s DiseaseNew England Journal of Medicine · 2022 · 5,761 citations

   BACKGROUND: The accumulation of soluble and insoluble aggregated amyloid-beta (Aβ) may initiate or potentiate pathologic processes in Alzheimer's disease. Lecanemab, a humanized IgG1 monoclonal antibody that binds with high affinity to Aβ soluble protofibrils, is being tested in persons with…

3. Clinical and Biomarker Changes in Dominantly Inherited Alzheimer's DiseaseNew England Journal of Medicine · 2012 · 3,918 citations

   BACKGROUND: The order and magnitude of pathologic processes in Alzheimer's disease are not well understood, partly because the disease develops over many years. Autosomal dominant Alzheimer's disease has a predictable age at onset and provides an opportunity to determine the…