Robert J. Vassar

Research topics

• Alzheimer's disease research and treatments · 2 papers
• Computational Drug Discovery Methods · 1 paper
• Cholinesterase and Neurodegenerative Diseases · 1 paper
• Prion Diseases and Protein Misfolding · 1 paper
• Nuclear Receptors and Signaling · 1 paper

Frequent co-authors

• Brian D. Bennett · 1 paper
• Safura Babu‐Khan · 1 paper
• Steve Kahn · 1 paper
• Elizabeth A. Mendiaz · 1 paper
• Paul E. Denis · 1 paper
• David B. Teplow · 1 paper
• Sandra L. Ross · 1 paper
• Patricia Amarante · 1 paper

Papers

1. β-Secretase Cleavage of Alzheimer's Amyloid Precursor Protein by the Transmembrane Aspartic Protease BACEScience · 1999 · 3,910 citations

   Cerebral deposition of amyloid beta peptide (Abeta) is an early and critical feature of Alzheimer's disease. Abeta generation depends on proteolytic cleavage of the amyloid precursor protein (APP) by two unknown proteases: beta-secretase and gamma-secretase. These proteases are prime therapeutic…

2. Intraneuronal β-Amyloid Aggregates, Neurodegeneration, and Neuron Loss in Transgenic Mice with Five Familial Alzheimer's Disease Mutations: Potential Factors in Amyloid Plaque FormationJournal of Neuroscience · 2006 · 3,680 citations

   Mutations in the genes for amyloid precursor protein (APP) and presenilins (PS1, PS2) increase production of beta-amyloid 42 (Abeta42) and cause familial Alzheimer's disease (FAD). Transgenic mice that express FAD mutant APP and PS1 overproduce Abeta42 and exhibit amyloid plaque…