William L. Klein

Research topics

• Alzheimer's disease research and treatments · 1 paper
• Computational Drug Discovery Methods · 1 paper
• Cholinesterase and Neurodegenerative Diseases · 1 paper

Frequent co-authors

• Mary P. Lambert · 1 paper
• Avlin K. Barlow · 1 paper
• Brett A. Chromy · 1 paper
• M. Liosatos · 1 paper
• Todd E. Morgan · 1 paper
• Irina Rozovsky · 1 paper
• Barbara L. Trommer · 1 paper
• Kirsten L. Viola · 1 paper

Papers

1. Diffusible, nonfibrillar ligands derived from Aβ 1–42 are potent central nervous system neurotoxinsProceedings of the National Academy of Sciences · 1998 · 3,550 citations

   Abeta1-42 is a self-associating peptide whose neurotoxic derivatives are thought to play a role in Alzheimer's pathogenesis. Neurotoxicity of amyloid beta protein (Abeta) has been attributed to its fibrillar forms, but experiments presented here characterize neurotoxins that assemble when fibril…