Timothy R. Mosmann

Research topics

• Monoclonal and Polyclonal Antibodies Research · 2 papers
• Immune Cell Function and Interaction · 1 paper
• T-cell and B-cell Immunology · 1 paper
• Immune Response and Inflammation · 1 paper
• Cytokine Signaling Pathways and Interactions · 1 paper

Frequent co-authors

• M W Bond · 2 papers
• Holly M. Cherwinski · 1 paper
• Martin A Giedlin · 1 paper
• Robert L. Coffman · 1 paper
• David Franklin Fiorentino · 1 paper

Papers

1. Two types of murine helper T cell clone. I. Definition according to profiles of lymphokine activities and secreted proteins.The Journal of Immunology · 1986 · 7,559 citations

   A panel of antigen-specific mouse helper T cell clones was characterized according to patterns of lymphokine activity production, and two types of T cell were distinguished. Type 1 T helper cells (TH1) produced IL 2, interferon-gamma, GM-CSF, and IL 3…

2. Two types of mouse T helper cell. IV. Th2 clones secrete a factor that inhibits cytokine production by Th1 clones.The Journal of Experimental Medicine · 1989 · 2,757 citations

   A cytokine synthesis inhibitory factor (CSIF) is secreted by Th2 clones in response to Con A or antigen stimulation, but is absent in supernatants from Con A-induced Th1 clones. CSIF can inhibit the production of IL-2, IL-3, lymphotoxin (LT)/TNF, IFN-gamma,…