Shimon Sakaguchi

Research topics

• Immune Cell Function and Interaction · 3 papers
• T-cell and B-cell Immunology · 3 papers
• CAR-T cell therapy research · 1 paper
• Immunotherapy and Immune Responses · 1 paper
• Cancer Immunotherapy and Biomarkers · 1 paper

Frequent co-authors

• Takashi Nomura · 2 papers
• Shohei Hori · 1 paper
• Kajsa Wing · 1 paper
• Yasushi Onishi · 1 paper
• Paz Prieto-Martin · 1 paper
• Tomoyuki Yamaguchi · 1 paper
• Makoto Miyara · 1 paper
• Zoltán Fehérvári · 1 paper

Papers

1. Control of Regulatory T Cell Development by the Transcription Factor Foxp3Science · 2003 · 8,242 citations

   Regulatory T cells engage in the maintenance of immunological self-tolerance by actively suppressing self-reactive lymphocytes. Little is known, however, about the molecular mechanism of their development. Here we show that Foxp3, which encodes a transcription factor that is genetically defective…

2. N aturally A rising CD4+R egulatory T C ells for I mmunologic S elf -T olerance and N egative C ontrol of I mmune R esponsesAnnual Review of Immunology · 2003 · 3,317 citations

   Naturally occurring CD4+ regulatory T cells, the majority of which express CD25, are engaged in dominant control of self-reactive T cells, contributing to the maintenance of immunologic self-tolerance. Their depletion or functional alteration leads to the development of autoimmune disease…

3. CTLA-4 Control over Foxp3 + Regulatory T Cell FunctionScience · 2008 · 2,965 citations

   Naturally occurring Foxp3+CD4+ regulatory T cells (Tregs) are essential for maintaining immunological self-tolerance and immune homeostasis. Here, we show that a specific deficiency of cytotoxic T lymphocyte antigen 4 (CTLA-4) in Tregs results in spontaneous development of systemic lymphoproliferation, fatal…