Mark A. Jarosinski

Research topics

• Alzheimer's disease research and treatments · 1 paper
• Computational Drug Discovery Methods · 1 paper
• Cholinesterase and Neurodegenerative Diseases · 1 paper

Frequent co-authors

• Robert J. Vassar · 1 paper
• Brian D. Bennett · 1 paper
• Safura Babu‐Khan · 1 paper
• Steve Kahn · 1 paper
• Elizabeth A. Mendiaz · 1 paper
• Paul E. Denis · 1 paper
• David B. Teplow · 1 paper
• Sandra L. Ross · 1 paper

Papers

1. β-Secretase Cleavage of Alzheimer's Amyloid Precursor Protein by the Transmembrane Aspartic Protease BACEScience · 1999 · 3,910 citations

   Cerebral deposition of amyloid beta peptide (Abeta) is an early and critical feature of Alzheimer's disease. Abeta generation depends on proteolytic cleavage of the amyloid precursor protein (APP) by two unknown proteases: beta-secretase and gamma-secretase. These proteases are prime therapeutic…