Jackson Lile
Amgen (United States)
1 paper in the Anchorcite directory, published in 1999, cited 3,910 times in total.
Research topics
Frequent co-authors
- Robert J. Vassar · 1 paper
- Brian D. Bennett · 1 paper
- Safura Babu‐Khan · 1 paper
- Steve Kahn · 1 paper
- Elizabeth A. Mendiaz · 1 paper
- Paul E. Denis · 1 paper
- David B. Teplow · 1 paper
- Sandra L. Ross · 1 paper
Papers
- β-Secretase Cleavage of Alzheimer's Amyloid Precursor Protein by the Transmembrane Aspartic Protease BACEScience · 1999 · 3,910 citations
Cerebral deposition of amyloid beta peptide (Abeta) is an early and critical feature of Alzheimer's disease. Abeta generation depends on proteolytic cleavage of the amyloid precursor protein (APP) by two unknown proteases: beta-secretase and gamma-secretase. These proteases are prime therapeutic…
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