D. E. Schmechel

Research topics

• Alzheimer's disease research and treatments · 3 papers
• Cholinesterase and Neurodegenerative Diseases · 2 papers
• Dementia and Cognitive Impairment Research · 2 papers
• Nuclear Receptors and Signaling · 1 paper
• Amyloidosis: Diagnosis, Treatment, Outcomes · 1 paper

Frequent co-authors

• Ann M. Saunders · 3 papers
• Warren J. Strittmatter · 3 papers
• Allen D. Roses · 2 papers
• Jeffery M. Vance · 2 papers
• Elizabeth H. Corder · 1 paper
• Perry C. Gaskell · 1 paper
• Gary W. Small · 1 paper
• J. L. Haines · 1 paper

Papers

1. Gene Dose of Apolipoprotein E Type 4 Allele and the Risk of Alzheimer's Disease in Late Onset FamiliesScience · 1993 · 9,614 citations

   The apolipoprotein E type 4 allele (APOE-epsilon 4) is genetically associated with the common late onset familial and sporadic forms of Alzheimer's disease (AD). Risk for AD increased from 20% to 90% and mean age at onset decreased from 84…

2. Apolipoprotein E: high-avidity binding to beta-amyloid and increased frequency of type 4 allele in late-onset familial Alzheimer disease.Proceedings of the National Academy of Sciences · 1993 · 4,321 citations

   Apolipoprotein E is immunochemically localized to the senile plaques, vascular amyloid, and neurofibrillary tangles of Alzheimer disease. In vitro, apolipoprotein E in cerebrospinal fluid binds to synthetic beta A4 peptide (the primary constituent of the senile plaque) with high avidity.…

3. Association of apolipoprotein E allele ϵ4 with late‐onset familial and sporadic Alzheimer's diseaseNeurology · 1993 · 3,829 citations

   Apolipoprotein E, type epsilon 4 allele (APOE epsilon 4), is associated with late-onset familial Alzheimer's disease (AD). There is high avidity and specific binding of amyloid beta-peptide with the protein ApoE. To test the hypothesis that late-onset familial AD may…