Skip to content
Anchorcite

Unresponsiveness to Cannabinoids and Reduced Addictive Effects of Opiates in CB 1 Receptor Knockout Mice

Catherine A. Ledent, Olga Valverde, G Cossu, François Petitet, Jean-François Aubert, F. Beslot, Georg Andrees Böhme, Assunta Impérato, Thierry Pedrazzini, Bernard Pierre Roques, Gilbert Vassart, Walter Fratta, Marc Parmentier

Science · 1999 · 3,624 citations

doi.org/10.1126/science.283.5400.401

Abstract

The function of the central cannabinoid receptor (CB1) was investigated by invalidating its gene. Mutant mice did not respond to cannabinoid drugs, demonstrating the exclusive role of the CB1 receptor in mediating analgesia, reinforcement, hypothermia, hypolocomotion, and hypotension. The acute effects of opiates were unaffected, but the reinforcing properties of morphine and the severity of the withdrawal syndrome were strongly reduced. These observations suggest that the CB1 receptor is involved in the motivational properties of opiates and in the development of physical dependence and extend the concept of an interconnected role of CB1 and opiate receptors in the brain areas mediating addictive behavior.

Cite this paper

Ledent, C. A., Valverde, O., Cossu, G., Petitet, F., Aubert, J.-F., Beslot, F., Böhme, G. A., Impérato, A., Pedrazzini, T., Roques, B. P., Vassart, G., Fratta, W., & Parmentier, M. (1999). Unresponsiveness to cannabinoids and reduced addictive effects of opiates in CB 1 receptor knockout mice. Science, 283(5400), 401–404. https://doi.org/10.1126/science.283.5400.401

Read it with every claim anchored

Add this paper to a project, ask questions of it, and get answers that point to the exact passage.

Start free

Related papers

  1. A Neural Substrate of Prediction and Reward1997
  2. Mitochondria and Apoptosis1998
  3. Parallel Organization of Functionally Segregated Circuits Linking Basal Ganglia and Cortex1986
  4. Emotion Circuits in the Brain2000
  5. Long‐lasting potentiation of synaptic transmission in the dentate area of the unanaesthetized rabbit following stimulation of the perforant path1973

Metadata from OpenAlex (CC0). Citations are generated from the published record.