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Mitochondria and Apoptosis

Douglas R. Green, John C. Reed

Science · 1998 · 9,050 citations

doi.org/10.1126/science.281.5381.1309

Abstract

A variety of key events in apoptosis focus on mitochondria, including the release of caspase activators (such as cytochrome c), changes in electron transport, loss of mitochondrial transmembrane potential, altered cellular oxidation-reduction, and participation of pro- and antiapoptotic Bcl-2 family proteins. The different signals that converge on mitochondria to trigger or inhibit these events and their downstream effects delineate several major pathways in physiological cell death.

Cite this paper

Green, D. R., & Reed, J. C. (1998). Mitochondria and apoptosis. Science, 281(5381), 1309–1312. https://doi.org/10.1126/science.281.5381.1309

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