Regulatory T Cells: Mechanisms of Differentiation and Function
Steven Zvi Josefowicz, Li‐Fan Lu, Alexander Yu Rudensky
Annual Review of Immunology · 2007 · 2,916 citationsOpen access
Abstract
The immune system has evolved to mount an effective defense against pathogens and to minimize deleterious immune-mediated inflammation caused by commensal microorganisms, immune responses against self and environmental antigens, and metabolic inflammatory disorders. Regulatory T (Treg) cell-mediated suppression serves as a vital mechanism of negative regulation of immune-mediated inflammation and features prominently in autoimmune and autoinflammatory disorders, allergy, acute and chronic infections, cancer, and metabolic inflammation. The discovery that Foxp3 is the transcription factor that specifies the Treg cell lineage facilitated recent progress in understanding the biology of regulatory T cells. In this review, we discuss cellular and molecular mechanisms in the differentiation and function of these cells.
Cite this paper
Josefowicz, S. Z., Lu, L., & Rudensky, A. Y. (2007). Regulatory T cells: Mechanisms of differentiation and function. Annual Review of Immunology, 30(1), 531–564. https://doi.org/10.1146/annurev.immunol.25.022106.141623
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