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Control of Viremia in Simian Immunodeficiency Virus Infection by CD8 + Lymphocytes

Jörn E. Schmitz, Marcelo J. Kuroda, Sampa Santra, Vito G. Sasseville, Meredith A. Simon, Michelle A. Lifton, Paul Rácz, Klara Tenner‐Racz, Margaret R. Dalesandro, Bernhard J. Scallon, John Ghrayeb, Meryl A. Forman, David C. Montefiori, E. Peter Rieber, Norman L. Letvin, Keith A. Reimann

Science · 1999 · 2,206 citations

doi.org/10.1126/science.283.5403.857

Abstract

Clinical evidence suggests that cellular immunity is involved in controlling human immunodeficiency virus-1 (HIV-1) replication. An animal model of acquired immune deficiency syndrome (AIDS), the simian immunodeficiency virus (SIV)-infected rhesus monkey, was used to show that virus replication is not controlled in monkeys depleted of CD8+ lymphocytes during primary SIV infection. Eliminating CD8+ lymphocytes from monkeys during chronic SIV infection resulted in a rapid and marked increase in viremia that was again suppressed coincident with the reappearance of SIV-specific CD8+ T cells. These results confirm the importance of cell-mediated immunity in controlling HIV-1 infection and support the exploration of vaccination approaches for preventing infection that will elicit these immune responses.

Cite this paper

Schmitz, J. E., Kuroda, M. J., Santra, S., Sasseville, V. G., Simon, M. A., Lifton, M. A., Rácz, P., Tenner‐Racz, K., Dalesandro, M. R., Scallon, B. J., Ghrayeb, J., Forman, M. A., Montefiori, D. C., Rieber, E. P., Letvin, N. L., & Reimann, K. A. (1999). Control of viremia in simian immunodeficiency virus infection by CD8 + lymphocytes. Science, 283(5403), 857–860. https://doi.org/10.1126/science.283.5403.857

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