Chronic Parkinsonism in Humans Due to a Product of Meperidine-Analog Synthesis
J. William Langston, Philip L. Ballard, James W. Tetrud, Ian Irwin
Science · 1983 · 4,939 citations
Abstract
Four persons developed marked parkinsonism after using an illicit drug intravenously. Analysis of the substance injected by two of these patients revealed primarily 1-methyl-4-phenyl-1,2,5,6-tetrahydropyridine (MPTP) with trace amounts of 1-methyl-4-phenyl-4-propionoxy-piperidine (MPPP). On the basis of the striking parkinsonian features observed in our patients, and additional pathological data from one previously reported case, it is proposed that this chemical selectively damages cells in the substantia nigra.
Cite this paper
Langston, J. W., Ballard, P. L., Tetrud, J. W., & Irwin, I. (1983). Chronic parkinsonism in humans due to a product of meperidine-analog synthesis. Science, 219(4587), 979–980. https://doi.org/10.1126/science.6823561
Read it with every claim anchored
Add this paper to a project, ask questions of it, and get answers that point to the exact passage.
Start freeRelated papers
- A Neural Substrate of Prediction and Reward1997
- Mitochondria and Apoptosis1998
- Parallel Organization of Functionally Segregated Circuits Linking Basal Ganglia and Cortex1986
- Emotion Circuits in the Brain2000
- Long‐lasting potentiation of synaptic transmission in the dentate area of the unanaesthetized rabbit following stimulation of the perforant path1973
Metadata from OpenAlex (CC0). Citations are generated from the published record.