Ian Irwin
1 paper in the Anchorcite directory, published in 1983, cited 4,939 times in total.
Research topics
- Neuroscience and Neuropharmacology Research · 1 paper
- Epilepsy research and treatment · 1 paper
- Pharmacological Effects and Toxicity Studies · 1 paper
Frequent co-authors
- J. William Langston · 1 paper
- Philip L. Ballard · 1 paper
- James W. Tetrud · 1 paper
Papers
- Chronic Parkinsonism in Humans Due to a Product of Meperidine-Analog SynthesisScience · 1983 · 4,939 citations
Four persons developed marked parkinsonism after using an illicit drug intravenously. Analysis of the substance injected by two of these patients revealed primarily 1-methyl-4-phenyl-1,2,5,6-tetrahydropyridine (MPTP) with trace amounts of 1-methyl-4-phenyl-4-propionoxy-piperidine (MPPP). On the basis of the striking parkinsonian features observed…
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