Central Memory and Effector Memory T Cell Subsets: Function, Generation, and Maintenance
Federica Sallusto, Jens Geginat, Antonio Lanzavecchia
Annual Review of Immunology · 2004 · 3,121 citations
Abstract
The memory T cell pool functions as a dynamic repository of antigen-experienced T lymphocytes that accumulate over the lifetime of the individual. Recent studies indicate that memory T lymphocytes contain distinct populations of central memory (TCM) and effector memory (TEM) cells characterized by distinct homing capacity and effector function. This review addresses the heterogeneity of TCM and TEM, their differentiation stages, and the current models for their generation and maintenance in humans and mice.
Cite this paper
Sallusto, F., Geginat, J., & Lanzavecchia, A. (2004). Central memory and effector memory T cell subsets: Function, generation, and maintenance. Annual Review of Immunology, 22(1), 745–763. https://doi.org/10.1146/annurev.immunol.22.012703.104702
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