René de Waal Malefyt

Research topics

• Immune Cell Function and Interaction · 2 papers
• Immunotherapy and Immune Responses · 2 papers
• T-cell and B-cell Immunology · 1 paper
• Immune Response and Inflammation · 1 paper

Frequent co-authors

• Kevin W. Moore · 1 paper
• Robert L. Coffman · 1 paper
• Anne O’Garra · 1 paper
• J S Abrams · 1 paper
• B Bennett · 1 paper
• Carl Gustav Figdor · 1 paper
• J E de Vries · 1 paper

Papers

1. Interleukin-10 and the Interleukin-10 ReceptorAnnual Review of Immunology · 2001 · 6,795 citations

   Interleukin-10 (IL-10), first recognized for its ability to inhibit activation and effector function of T cells, monocytes, and macrophages, is a multifunctional cytokine with diverse effects on most hemopoietic cell types. The principal routine function of IL-10 appears to be…

2. Interleukin 10(IL-10) inhibits cytokine synthesis by human monocytes: an autoregulatory role of IL-10 produced by monocytes.The Journal of Experimental Medicine · 1991 · 3,831 citations

   In the present study we demonstrate that human monocytes activated by lipopolysaccharides (LPS) were able to produce high levels of interleukin 10 (IL-10), previously designated cytokine synthesis inhibitory factor (CSIF), in a dose dependent fashion. IL-10 was detectable 7 h…