Douglas D. Richman

Research topics

• HIV Research and Treatment · 5 papers
• HIV/AIDS Research and Interventions · 5 papers
• HIV/AIDS drug development and treatment · 4 papers
• HIV-related health complications and treatments · 1 paper

Frequent co-authors

• Paul A. Volberding · 2 papers
• Joseph J. Eron · 2 papers
• Diane V. Havlir · 2 papers
• Diana Finzi · 1 paper
• Monika Hermankova · 1 paper
• Theodore C. Pierson · 1 paper
• Lucy M. Carruth · 1 paper
• Christopher B. Buck · 1 paper

Papers

1. Identification of a Reservoir for HIV-1 in Patients on Highly Active Antiretroviral TherapyScience · 1997 · 3,172 citations

   The hypothesis that quiescent CD4+ T lymphocytes carrying proviral DNA provide a reservoir for human immunodeficiency virus-type 1 (HIV-1) in patients on highly active antiretroviral therapy (HAART) was examined. In a study of 22 patients successfully treated with HAART for…

2. The Efficacy of Azidothymidine (AZT) in the Treatment of Patients with AIDS and AIDS-Related ComplexNew England Journal of Medicine · 1987 · 3,003 citations

   We conducted a double-blind, placebo-controlled trial of oral azidothymidine (AZT) in 282 patients with the acquired immunodeficiency syndrome (AIDS) or AIDS-related complex. Although significant clinical benefit was documented (N Engl J Med 1987; 317:185-91), serious adverse reactions, particularly bone marrow…

3. Antiretroviral Treatment of Adult HIV InfectionJAMA · 2012 · 2,475 citations

   CONTEXT: New trial data and drug regimens that have become available in the last 2 years warrant an update to guidelines for antiretroviral therapy (ART) in human immunodeficiency virus (HIV)-infected adults in resource-rich settings. OBJECTIVE: To provide current recommendations for…

4. Recovery of Replication-Competent HIV Despite Prolonged Suppression of Plasma ViremiaScience · 1997 · 2,256 citations

   In evaluating current combination drug regimens for treatment of human immunodeficiency virus (HIV) disease, it is important to determine the existence of viral reservoirs. After depletion of CD8 cells from the peripheral blood mononuclear cells (PBMCs) of both patients and…

5. Treatment with Indinavir, Zidovudine, and Lamivudine in Adults with Human Immunodeficiency Virus Infection and Prior Antiretroviral TherapyNew England Journal of Medicine · 1997 · 1,925 citations

   BACKGROUND: The new protease inhibitors are potent inhibitors of the human immunodeficiency virus (HIV), and in combination with other antiretroviral drugs they may be able to cause profound and sustained suppression of HIV replication. METHODS: In this double-blind study, 97…