Alan S. Perelson

Research topics

• HIV Research and Treatment · 3 papers
• HIV/AIDS drug development and treatment · 2 papers
• Hepatitis C virus research · 2 papers
• HIV/AIDS Research and Interventions · 1 paper
• Systemic Lupus Erythematosus Research · 1 paper

Frequent co-authors

• Avidan Uriel Neumann · 2 papers
• Martin H. Markowitz · 1 paper
• John M. Leonard · 1 paper
• David D. Ho · 1 paper
• Nancy P. Lam · 1 paper
• Harel Dahari · 1 paper
• David R. Gretch · 1 paper
• Thelma E. Wiley · 1 paper

Papers

1. HIV-1 Dynamics in Vivo: Virion Clearance Rate, Infected Cell Life-Span, and Viral Generation TimeScience · 1996 · 3,598 citations

   A new mathematical model was used to analyze a detailed set of human immunodeficiency virus-type 1 (HIV-1) viral load data collected from five infected individuals after the administration of a potent inhibitor of HIV-1 protease. Productively infected cells were estimated…

2. Hepatitis C Viral Dynamics in Vivo and the Antiviral Efficacy of Interferon-α TherapyScience · 1998 · 2,131 citations

   To better understand the dynamics of hepatitis C virus and the antiviral effect of interferon-alpha-2b (IFN), viral decline in 23 patients during therapy was analyzed with a mathematical model. The analysis indicates that the major initial effect of IFN is…

3. Identification and characterization of transmitted and early founder virus envelopes in primary HIV-1 infectionProceedings of the National Academy of Sciences · 2008 · 1,977 citations

   The precise identification of the HIV-1 envelope glycoprotein (Env) responsible for productive clinical infection could be instrumental in elucidating the molecular basis of HIV-1 transmission and in designing effective vaccines. Here, we developed a mathematical model of random viral evolution…