The Chlamydomonas Genome Reveals the Evolution of Key Animal and Plant Functions
Sabeeha Merchant, Simon E. Prochnik, Olivier Vallon, Elizabeth H. Harris, Steven J. Karpowicz, George B. Witman, Astrid Terry, Asaf A. Salamov, Lillian K. Fritz‐Laylin, Laurence Maréchal‐Drouard, Wallace F. Marshall, Liang‐Hu Qu, David R. Nelson, Anton A. Sanderfoot, Martin H. Spalding, Vladimir V. Kapitonov, Qinghu Ren, Patrick J. Ferris, Erika Lindquist, Harris Shapiro, Susan M. Lucas, Jane Grimwood, Jeremy Schmutz, Pierre Cardol, Heriberto Cerutti, Guillaume Chanfreau, Chun-Long Chen, Valérie Cognat, Martin T. Croft, Rachel M. Dent, Susan K. Dutcher, Emilio Muñoz Fernández, Hideya Fukuzawa, David González-Ballester, Diego González‐Halphen, Armin Hallmann, Marc Hanikenne, Michael Hippler, William B. Inwood, Kamel Jabbari, Ming Kalanon, Richard Kuras, Paul A. Lefebvre, Stéphane D. Lemaire, Alexey V. Lobanov, Martin Lohr, Andrea L. Manuell, Iris Meier, Laurens Mets, Maria Mittag, Telsa M. Mittelmeier, James V. Moroney, Jeffrey L Moseley, Carolyn A. Napoli, Aurora M. Nedelcu, Krishna Niyogi, Sergey V. Novoselov, Ian T. Paulsen, Gregory J. Pazour, Saul Purton, Jean-Philippe F. Ral, Diego Mauricio Riaño‐Pachón, Wayne Russell Riekhof, Linda A. Rymarquis, Michael Schroda, David Thomas Stern, James Umen, Robert D. Willows, Nedra F. Wilson, Sara L. Zimmer, Jens Allmer, Janneke Balk, Kateřina Bišová, Chongjian Chen, Marek Eliáš, Karla Gendler, Charles R. Hauser, Mary Rose Lamb, Heidi K. Ledford, Joanne C. Long, Jun Minagawa, Mark Dudley Page, Junmin Pan, Wirulda Pootakham, Sanja Roje, Annkatrin Rose, Eric A. Stahlberg, Aimee M. Terauchi, Pinfen Yang, Steven G. Ball, Chris Bowler, Carol L. Dieckmann, Vadim N. Gladyshev, Richard E. Jorgensen, Stephen Patrick Mayfield, Bernd Mueller‐Roeber, Sathish Rajamani, Richard T. Sayre, Peter B Brokstein
Science · 2007 · 2,798 citationsOpen access
Abstract
Chlamydomonas reinhardtii is a unicellular green alga whose lineage diverged from land plants over 1 billion years ago. It is a model system for studying chloroplast-based photosynthesis, as well as the structure, assembly, and function of eukaryotic flagella (cilia), which were inherited from the common ancestor of plants and animals, but lost in land plants. We sequenced the approximately 120-megabase nuclear genome of Chlamydomonas and performed comparative phylogenomic analyses, identifying genes encoding uncharacterized proteins that are likely associated with the function and biogenesis of chloroplasts or eukaryotic flagella. Analyses of the Chlamydomonas genome advance our understanding of the ancestral eukaryotic cell, reveal previously unknown genes associated with photosynthetic and flagellar functions, and establish links between ciliopathy and the composition and function of flagella.
Cite this paper
Merchant, S., Prochnik, S. E., Vallon, O., Harris, E. H., Karpowicz, S. J., Witman, G. B., Terry, A., Salamov, A. A., Fritz‐Laylin, L. K., Maréchal‐Drouard, L., Marshall, W. F., Qu, L., Nelson, D. R., Sanderfoot, A. A., Spalding, M. H., Kapitonov, V. V., Ren, Q., Ferris, P. J., Lindquist, E., … Brokstein, P. B. (2007). The chlamydomonas genome reveals the evolution of key animal and plant functions. Science, 318(5848), 245–250. https://doi.org/10.1126/science.1143609
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