Regulation of Synaptic Efficacy by Coincidence of Postsynaptic APs and EPSPs
Henry Markram, Joachim H. R. Lübke, Michael Frotscher, Bert J. Sakmann
Science · 1997 · 3,955 citationsOpen access
Abstract
Activity-driven modifications in synaptic connections between neurons in the neocortex may occur during development and learning. In dual whole-cell voltage recordings from pyramidal neurons, the coincidence of postsynaptic action potentials (APs) and unitary excitatory postsynaptic potentials (EPSPs) was found to induce changes in EPSPs. Their average amplitudes were differentially up- or down-regulated, depending on the precise timing of postsynaptic APs relative to EPSPs. These observations suggest that APs propagating back into dendrites serve to modify single active synaptic connections, depending on the pattern of electrical activity in the pre- and postsynaptic neurons.
Cite this paper
Markram, H., Lübke, J. H. R., Frotscher, M., & Sakmann, B. J. (1997). Regulation of synaptic efficacy by coincidence of postsynaptic APs and EPSPs. Science, 275(5297), 213–215. https://doi.org/10.1126/science.275.5297.213
Read it with every claim anchored
Add this paper to a project, ask questions of it, and get answers that point to the exact passage.
Start freeRelated papers
- An Integrative Theory of Prefrontal Cortex Function2001
- The Brain's Default Network2008
- A Neural Substrate of Prediction and Reward1997
- Emotion Circuits in the Brain2000
- Long‐lasting potentiation of synaptic transmission in the dentate area of the unanaesthetized rabbit following stimulation of the perforant path1973
Metadata from OpenAlex (CC0). Citations are generated from the published record.