Cancer Immunoediting: Integrating Immunity’s Roles in Cancer Suppression and Promotion
Robert D. Schreiber, Lloyd J. Old, Mark John Smyth
Science · 2011 · 6,614 citations
Abstract
Understanding how the immune system affects cancer development and progression has been one of the most challenging questions in immunology. Research over the past two decades has helped explain why the answer to this question has evaded us for so long. We now appreciate that the immune system plays a dual role in cancer: It can not only suppress tumor growth by destroying cancer cells or inhibiting their outgrowth but also promote tumor progression either by selecting for tumor cells that are more fit to survive in an immunocompetent host or by establishing conditions within the tumor microenvironment that facilitate tumor outgrowth. Here, we discuss a unifying conceptual framework called "cancer immunoediting," which integrates the immune system's dual host-protective and tumor-promoting roles.
Cite this paper
Schreiber, R. D., Old, L. J., & Smyth, M. J. (2011). Cancer immunoediting: Integrating Immunity’s roles in cancer suppression and promotion. Science, 331(6024), 1565–1570. https://doi.org/10.1126/science.1203486
Read it with every claim anchored
Add this paper to a project, ask questions of it, and get answers that point to the exact passage.
Start freeRelated papers
- Integrated analysis of multimodal single-cell data2021
- Macrophage plasticity and polarization: in vivo veritas2012
- The M1 and M2 paradigm of macrophage activation: time for reassessment2014
- Obesity induces a phenotypic switch in adipose tissue macrophage polarization2007
- Synaptic Pruning by Microglia Is Necessary for Normal Brain Development2011
Metadata from OpenAlex (CC0). Citations are generated from the published record.