Todd R. Golub

Research topics

• Computational Drug Discovery Methods · 1 paper
• Bioinformatics and Genomic Networks · 1 paper
• Gene Regulatory Network Analysis · 1 paper
• Mitochondrial Function and Pathology · 1 paper
• Alzheimer's disease research and treatments · 1 paper
• Trace Elements in Health · 1 paper

Frequent co-authors

• Justin Lamb · 1 paper
• Emily D. Crawford · 1 paper
• David D. Peck · 1 paper
• Joshua W. Modell · 1 paper
• Irene C. Blat · 1 paper
• Matthew J. Wrobel · 1 paper
• Jim Lerner · 1 paper
• Jean-Philippe Brunet · 1 paper

Papers

1. The Connectivity Map: Using Gene-Expression Signatures to Connect Small Molecules, Genes, and DiseaseScience · 2006 · 5,554 citations

   To pursue a systematic approach to the discovery of functional connections among diseases, genetic perturbation, and drug action, we have created the first installment of a reference collection of gene-expression profiles from cultured human cells treated with bioactive small molecules,…

2. Copper induces cell death by targeting lipoylated TCA cycle proteinsScience · 2022 · 5,052 citations

   Copper is an essential cofactor for all organisms, and yet it becomes toxic if concentrations exceed a threshold maintained by evolutionarily conserved homeostatic mechanisms. How excess copper induces cell death, however, is unknown. Here, we show in human cells that…