George F. Koob
Scripps Clinic
1 paper in the Anchorcite directory, published in 1997, cited 2,561 times in total.
ORCID profileResearch topics
- Neurotransmitter Receptor Influence on Behavior · 1 paper
- Stress Responses and Cortisol · 1 paper
- Tryptophan and brain disorders · 1 paper
Frequent co-authors
- Michel Le Moal · 1 paper
Papers
- Drug Abuse: Hedonic Homeostatic DysregulationScience · 1997 · 2,561 citations
Understanding the neurobiological mechanisms of addiction requires an integration of basic neuroscience with social psychology, experimental psychology, and psychiatry. Addiction is presented as a cycle of spiralling dysregulation of brain reward systems that progressively increases, resulting in compulsive drug use…
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